Frances M. K. Williams

The genetic architecture of fibromyalgia across 2.5 million individuals

This study identifies 26 risk loci for fibromyalgia through a genome-wide association analysis of 2.5 million individuals, revealing genetic links to neural functions and chronic pain disorders.

Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus

The paper integrates GWAS meta-analysis with human brain cell mapping to identify genetic loci and cell types involved in tinnitus, implicating the amygdala and midbrain.

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

This study identifies 16 new genetic loci associated with plasma N-glycosylation in 10,000 individuals and links them to liver disease and inflammatory proteins.

Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Widespread Pain in the UK Biobank (N=172,230)

This study identifies a novel genetic variant associated with widespread pain using UK Biobank data and finds sex-specific genetic differences.

Decomposing the genetic background of chronic back pain

This paper decomposes the genetic background of chronic back pain into shared and unshared components, identifying genes associated with different subphenotypes and biological pathways.

Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss

Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain

This study identifies three genetic loci associated with chronic widespread musculoskeletal pain, with the RNF123 locus replicated in independent cohorts.

Genetic variation in RCOR1 is associated with tinnitus in UK Biobank

This study identifies genetic variants near RCOR1 associated with tinnitus in UK Biobank, suggesting a potential role for RCOR1 in tinnitus pathogenesis.

Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

The paper identifies heritable symptoms of SARS-CoV-2 infection using twin studies of self-reported symptoms from the TwinsUK cohort.

Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain at different anatomic sites

The paper identifies shared genetic factors for chronic musculoskeletal pain across different anatomic sites using genetically independent phenotypes derived from UK Biobank data.

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

This study identifies 3 genetic loci associated with neck or shoulder pain using UK Biobank data, with partial replication in Generation Scotland.

Defining the genetic control of human blood plasma N-glycome using genome-wide association study

This study identifies twelve genetic loci associated with human blood plasma N-glycome composition through genome-wide association analysis, revealing both direct and indirect genetic influences on glycosylation.

Genome-wide association study identifies 44 independent genomic loci for self-reported adult hearing difficulty in the UK Biobank cohort

Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals

This study conducts a large GWAS on back pain, identifies genetic loci, and explores genetic correlations with risk factors, revealing complex genetic architecture and molecular pathways.

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

This paper conducts a genome-wide meta-analysis of chronic back pain in 158,025 individuals, identifying three genetic loci associated with the condition.

Increased DNA methylation variability in rheumatoid arthritis discordant monozygotic twins

The paper identifies a differentially variable DNA methylation signature in rheumatoid arthritis discordant monozygotic twins, suggesting epigenetic variability contributes to autoimmune disease.