Voluntary exercise during weight loss attenuates adipose CD8+ T cell exhaustion that persists after weight regain
Okechukwu Kingsley Oforka, Emily C. P. LaVoy, Matthew A. Cottam, Munira Kapadia, Emily Nguyen, Caroline Hegemann, Alyssa H. Hasty, Nathan C. Winn, Heather L. Caslin
This study shows that voluntary exercise during weight loss reduces adipose CD8+ T cell exhaustion, which persists even after weight regain, but does not improve glucose tolerance or macrophage inflammation.
bioRxiv · Jul 28, 2026 · PreprintImmunology