Zika virus oncolytic signaling reverts immunosuppressive and angiogenic glioblastoma microenvironment in vitro and in vivo
Gabriella Pinheiro A. de Freitas, Jefferson Henrique Quintanilla, José Marcos Janeiro, Oleksandra Brechko, Romy Weinstock, Gabriel Cardoso Atella, Matheus Villanueva Andrade, Jéssica C. C. G. Ferreira, Janaina M.de Vasconcelos, João Vianez, Maria Bellio, Amílcar Tanuri, Luiz Gustavo Dubois, Flavia R. S. Lima, Vivaldo Moura‐Neto, , Patricia Pestana Garcez
This study shows that Zika virus reprograms the glioblastoma tumor microenvironment to be anti-tumoral by inducing type III interferon signaling, which can be mimicked by exogenous treatment.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology