Author

Megan Major

University of California, Los AngelesORCID 0000-0002-9684-8844Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Bogdan PaşaniuciD· 2 shared Nicholas MancusoiD· 2 shared Alexander GuseviD· 1 shared Arunabha MajumdariD· 1 shared Dominic FurnissiD· 1 shared Helian FengiD· 1 shared Kathryn S. BurchiD· 1 shared Malika Kumar FreundiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenetics

Bogdan PaşaniucORCID

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2 papers

Recent·Most cited

Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS)

Helian Feng, Nicholas Mancuso, Alexander Gusev, Arunabha Majumdar, Megan Major, Bogdan Paşaniuc, Peter Kraft

This paper improves transcriptome-wide association study (TWAS) power by integrating multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests, identifying more gene-trait associations.

PLoS Genetics · Apr 8, 2021Peer-reviewedGenetics

Integrative analysis of Dupuytren’s disease identifies novel risk locus and reveals a shared genetic etiology with BMI

Megan Major, Malika Kumar Freund, Kathryn S. Burch, Nicholas Mancuso, Michael Ng, Dominic Furniss, Bogdan Paşaniuc, Roel A. Ophoff

This study identifies 43 tissue-specific gene associations with Dupuytrens disease risk and finds significant genetic correlations with BMI, type II diabetes, and lipid traits.

Genetic Epidemiology · May 13, 2019Peer-reviewedGenetics