Engineering protein expression dynamics with Tet-ON and dTAG degron systems: from precise control to oscillations
Benjamin Noble, Oliver Cottrell, Andrew Rowntree, Veronica Biga, Florence Woods, Xinjie Wang, Nancy Papalopulu, Anzy Miller
The paper introduces a framework for engineering tunable oscillatory protein expression using Tet-On and dTAG degron systems, demonstrating synchronous oscillations with the COD system.
bioRxiv · Dec 19, 2025 · PreprintDevelopmental Biology