Veronica Biga

Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif

The paper shows that oscillatory co-expression of HES1 and HES5 allows hybrid states in a bistable transcription factor motif by enabling phase-locking and entrainment.

Ciliary cAMP regulates Shh signal interpretation to drive polarisation of differentiating neurons

This study shows that ciliary cAMP levels regulate Shh signal interpretation during neuron differentiation by balancing Smo and GPR161 to control actin dynamics and polarisation.

Engineering protein expression dynamics with Tet-ON and dTAG degron systems: from precise control to oscillations

The paper introduces a framework for engineering tunable oscillatory protein expression using Tet-On and dTAG degron systems, demonstrating synchronous oscillations with the COD system.

NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation

This study shows NGN3 protein oscillations control timing of human pancreatic endocrine differentiation, not fate, through fold-change detection via an incoherent feedforward motif.

Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis

The paper investigates how cellular protrusions in mouse spinal cord neural progenitors enable long-distance Notch signaling, affecting HES5 expression patterns.

Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness

The paper shows that cell coupling compensates for altered Her6 dynamics in zebrafish neural progenitors, maintaining phenotypic robustness despite single-cell expression changes.

A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.

The paper identifies spatially periodic HES5 microclusters in the mouse spinal cord during neurogenesis, showing their dynamic regulation by Notch signaling and their role in progenitor differentiation.

miR-9 mediated noise optimization of the her6 oscillator is needed for cell state progression in the Zebrafish hindbrain

The paper shows that miR-9 optimizes noise in the Her6 oscillator, enabling cell state progression in zebrafish hindbrain neurogenesis.

Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis

The paper uses live imaging and mathematical modeling to show HES5 protein dynamics correlate with cell-state transitions and fate decisions in murine neurogenesis.