Carolyn Sangokoya

Coordinate post-transcriptional regulation by microRNAs and RNA binding proteins is critical for early embryonic cell fate decisions

The paper shows that coordinated regulation of the Pfn2 transcript by microRNAs and RNA binding proteins is essential for ESC differentiation into germ layer lineages.

MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis

This study identifies a miR-290-PFN2 axis that regulates endocytosis and ERK signaling, affecting ESC self-renewal and differentiation.