Silvia Affò

This study shows that the cell-of-origin, not oncogenic pathway activation, determines the desmoplastic immune-excluded tumor microenvironment in KRAS-driven liver cancer.

This study develops patient-derived liver biopsy organoids to model alcohol-associated liver disease and identifies disease-specific features and therapeutic responses.

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.