Vivek Modi

Kincore provides a web resource for classifying kinase conformations and inhibitor types using structural data from the PDB.

The paper presents a structure-based multiple sequence alignment of 497 human protein kinase domains and identifies ten kinases that can be confidently placed into the CAMK group.

The paper clusters kinase activation loop conformations using structural features and introduces a nomenclature to classify active and inactive states based on DFG motif positioning and backbone angles.