Mechanistic Basis of Sulfo Transfer in a PAPS-Independent ArylSulfate SulfoTransferases Revealed by Crystallography and QM/MM Simulations
Dilara Balci, Nina Marietta Nimbona, Haya Obeid, Aurélie Delavat, Lionel Cladière, Cyrille Grandjean, Mirjam Czjzek, Franck Daligault, Mehdi D. Davari
This paper elucidates the catalytic mechanism of a PAPS-independent ASST using crystallography and QM/MM simulations, revealing a two-histidine mechanism for sulfo transfer.
bioRxiv · Oct 9, 2026 · PreprintBiochemistry