Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1
Tamir Edri, Tali Abbou, Dor Cohen, José Manuel Inácio, Yehuda Shabtai, Graciela Pillemer, José António Belo, Abraham Fainsod
This paper identifies ALDH1L1 as the enzyme linking folic acid to retinoic acid signaling in preventing neural tube defects.
Proceedings of the National Academy of Sciences · Jul 30, 2026Peer-reviewedDevelopmental Biology