Single-cell copy number lineage tracing enabling gene discovery
Fang Wang, Qihan Wang, Vakul Mohanty, Shaoheng Liang, Jinzhuang Dou, Jincheng Han, Darlan Conterno Minussi, Ruli Gao, Li Ding, Nicholas E. Navin, Ken Chen
The paper introduces MEDALT and LSA to reconstruct copy number lineage trees from single-cell data and identify fitness-associated genes, showing improved accuracy over phylogenetics methods in cancer datasets.
Genome biology · Feb 23, 2021Peer-reviewedBioinformatics