Fang Wang

Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.

Single-cell copy number lineage tracing enabling gene discovery

The paper introduces MEDALT and LSA to reconstruct copy number lineage trees from single-cell data and identify fitness-associated genes, showing improved accuracy over phylogenetics methods in cancer datasets.

Ab initio Spillover Compensation in CyTOF Data

This paper introduces CytoSpill, a statistical method to correct spillover effects in CyTOF data without single-stained controls, improving clustering accuracy and enabling novel subpopulation discovery.

Latent periodic process inference from single-cell RNA-seq data

Cyclum improves cell-cycle characterization in scRNA-seq data, enhancing subpopulation delineation and cell atlas construction.

SCMarker: ab initio marker selection for single cell transcriptome profiling

SCMarker identifies cell-type-discriminative markers in scRNA-seq data through unsupervised analysis of gene expression patterns without prior knowledge.