Author

Sam Trejo

Princeton UniversityORCID 0000-0002-9880-5354Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Organism:human· 1 Research Focus:polygenic risk· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Benjamin W. DomingueiD· 2 shared Arbel HarpakiD· 1 shared Dalton ConleyiD· 1 shared Elliot M. Tucker–DrobiD· 1 shared Klint KanopkaiD· 1 shared Ramina SotoudehiD· 1 shared Travis T. MallardiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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2 shared papersGenetics

Benjamin W. DomingueORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintMay 3, 2024

Does standard adjustment for genomic population structure capture direct genetic effects?

Ramina Sotoudeh, Sam Trejo, Arbel Harpak, Dalton Conley

This study examines whether adjusting for population structure via principal components (PCs) in GWAS and polygenic index analyses reduces detectable direct genetic effects, finding minimal impact on polygenic effects.

3 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GeneticsbioRxivPreprintSep 8, 2020

Distinguishing between interaction and dispersion effects in the analysis of gene-environment interaction

Benjamin W. Domingue, Klint Kanopka, Travis T. Mallard…·Elliot M. Tucker–Drob

The paper develops a statistical method to distinguish between interaction and dispersion effects in gene-environment interactions, applying it to BMI data.

DOI 10.1101/2020.09.08.287888

GWAS summary statisticsstatistical model

𝕏 PostBluesky

GenomicsbioRxivPreprintJul 31, 2019

Genetic Nature or Genetic Nurture? Quantifying Bias in Analyses Using Polygenic Scores

Sam Trejo, Benjamin W. Domingue

The paper quantifies bias in polygenic score analyses due to genetic nurture effects, showing opposite biases in OLS and family fixed effects regressions.

27 citations

GWAS summary statisticsstatistical model

𝕏 PostBluesky