Author

Annabel Perry

Broad InstituteORCID 0000-0002-9904-0824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ali AkbariiD· 2 shared Alkes L. PriceiD· 2 shared David ReichiD· 2 shared Alex C. KeeneiD· 1 shared Alison R. BartoniD· 1 shared Alissa MittnikiD· 1 shared Buu Minh Thanh TruongiD· 1 shared Eric S. LanderiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersEvolutionary Biology

Ali AkbariORCID

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3 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintApr 14, 2026

Ancient DNA reveals that natural selection has upregulated the immune system over the last 10,000 years

Javier Maravall-López, Buu Minh Thanh Truong, Gaspard Kerner…·Alkes L. Price

This study uses ancient DNA and genomic data to show natural selection has strengthened the immune system over 10,000 years, with both protective and harmful effects on immune-related diseases.

1 citation

humanwhole-genome sequencing

Evolutionary BiologybioRxivPreprintSep 14, 2024

Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation

Ali Akbari, Alison R. Barton, Steven Gazal…·David Reich

This paper detects widespread directional selection in ancient DNA data, identifying 347 genome-wide significant loci and linking them to traits like body fat, skin color, and cognitive performance.

53 citations

humanDNA methylation

BioinformaticsG3 Genes Genomes GeneticsPeer-reviewedJun 16, 2022

CaveCrawler: An interactive analysis suite for cavefish bioinformatics

Annabel Perry, Suzanne E. McGaugh, Alex C. Keene, Heath Blackmon

CaveCrawler integrates genomic and transcriptional data from Astyanax mexicanus to compare gene expression and selection markers between surface and cave populations.

DOI 10.1093/g3journal/jkac132

mousebulk RNA-seq