Alex C. Keene

The paper compares microglial cell biology between surface and cave populations of Astyanax mexicanus, finding increased microglia numbers and altered lysosomal activity in cavefish.

This study shows that Drosophila with APOE4 variants exhibit AD-like phenotypes under stress and metabolic challenges, supporting a multi-hit model of disease.

The paper identifies MEIS1 as a gene involved in sleep abnormalities and cerebellar development using cross-species variant-to-function analyses in zebrafish.

The paper presents a spatial cell atlas comparing surface and cave-dwelling Mexican tetra fish brains, revealing transcriptional changes across cell types linked to cave adaptation.

The paper investigates how a central dopamine circuit evolves in blind cavefish to adapt light-evoked sensorimotor responses, revealing its role in behavioral adaptation through functional and genetic analysis.

This study creates a single-cell atlas of Mexican cavefish brains, revealing differences in cell types and gene expression linked to evolved disease resilience.

The paper identifies cell-type-specific genes regulating sleep by mapping GWAS variants to effector genes in human and Drosophila models, revealing ruby/AP3B2 as a conserved glial regulator.

The paper investigates genetic repeatability in cavefish traits using QTL mapping, finding shared genomic regions for eye loss but less repeatability for sleep and metabolic traits.

This study shows that sleep restoration in aged Drosophila improves glial clearance of damaged axons by restoring Draper expression and transcriptional responses to injury.

This study investigates how sleep at different life stages affects longevity in Drosophila, finding that early life sleep is positively associated with longer lifespan.

This study identifies CCHa2 as a neuropeptide secreted by the fat body that signals insulin-producing cells in the brain to regulate sleep in Drosophila.

The paper identifies recurrent deletions in cavefish genomes linked to adaptive traits, showing their role in repeated evolution through positive selection.

The paper investigates DNA damage and cellular stress in short-sleeping Mexican cavefish, finding elevated DNA damage markers and reduced DNA repair responses compared to surface fish.

This study examines sleep loss in cavefish populations and finds it is widespread and evolutionarily convergent across multiple lineages.

This study uses computer vision to analyze locomotor behavior in Lake Malawi cichlids, revealing cryptic behavioral differences that may contribute to niche partitioning.

The paper examines multi-trait evolution in cavefish, finding shared and distinct genetic mechanisms and evidence for pleiotropy or linkage in trait evolution.

This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.

This study shows that blood-derived dietary protein increases sleep and reduces activity in Aedes aegypti mosquitoes, suggesting a role for protein in regulating postprandial sleep behavior.

The paper uses neural networks to analyze stress-like behaviors in cave and surface-dwelling Astyanax mexicanus, finding differences in freezing, bottom-dwelling, and hyperactivity.

This paper describes an intergenerational classroom model combining undergraduate students and lifelong learners in a biology education course, showing high satisfaction and positive outcomes for both groups.

The paper identifies genes regulating sleep-metabolism interactions in Drosophila LHLK neurons using single-cell sequencing and functional validation.

This study characterizes the CRY1 R263Q mutation in subterranean animals, showing altered circadian rhythms and gene expression in mice, but no major metabolic defects.

This study shows that oca2 mutations in Mexican tetra affect prey capture behavior, with albino fish using vision in light and lateral line in dark, impacting competitive success in different environments.

The paper investigates postprandial sleep in Mexican cavefish and surface fish, finding that larvae exhibit postprandial sleep while adults do not, suggesting its role in energy conservation.

This study shows aging impairs sugar taste response in fruit flies, but not fatty acids, and links this to specific neuronal changes and AD-like mechanisms.

This paper presents chromosome-scale assemblies of Astyanax mexicanus surface and cave populations to study genetic basis of adaptation to cave environments.

This study investigates the role of Neurofibromin 1 (Nf1) in regulating sleep depth and metabolic rate in Drosophila, finding that Nf1 deficiency disrupts sleep consolidation and gut homeostasis.

This study identifies rs3752495 as the causal variant at the insomnia WDR90 GWAS locus that influences PIG-Q expression through a regulatory mechanism.

The paper maps structural brain evolution to anatomical modules by analyzing volume and shape variability in cavefish and hybrids.

The paper identifies GPI-anchor biosynthesis as a conserved regulator of sleep through variant-to-gene mapping and cross-species genetic screening in humans and model organisms.