Leveraging T-cell receptor - epitope recognition models to disentangle unique and cross-reactive T-cell response to SARS-CoV-2 during COVID-19 progression/resolution
Anna Postovskaya, Alexandra Vujkovic, Tessa de Block, Lida van Petersen, Maartje Van Frankenhuijsen, Isabel Brosius, Emmanuel Bottieau, Christophe Van Dijck, Caroline Theunissen, Sabrina H. van Ierssel, Erika Vlieghe, Esther Bartholomeus, Kerry A. Mullan, Wim J. Adriaensen, Guido L. Vanham, , Pieter Meysman
The paper uses TCR-epitope recognition models to analyze CD8+ T-cell responses in COVID-19 patients, finding that non-critical patients develop unique SARS-CoV-2-specific T-cell responses not seen in critical patients.
Frontiers in Immunology · May 31, 2023Peer-reviewedBioinformatics