Esther Bartholomeus

This study tracks CD4+ T cell and IgG responses over time after yellow fever vaccination, showing peak activation at day 22 and long-term antibody persistence.

The paper introduces AIRRWAS, a framework to identify T cell receptor convergence with bacterial genera, revealing reproducible associations across cohorts and functional T cell responses.

The paper creates a synovial fluid TCR, cytokine, and cell repertoire atlas to compare disease mechanisms across arthritic conditions using systems immunology approaches.

The paper links immunotypes and enterotypes through a systems immunology approach, showing they are orthogonal and connected via the blood transcriptome, with associations between specific bacteria and immune health.

The paper develops computational models to identify WT1-specific TCRs in AML patients and finds higher TCR diversity in remission compared to relapsed patients.

This study uses multi-view modelling to improve prediction of HBV vaccine response by integrating bulk RNA-seq, T-cell data, flow cytometry, and clinical metadata.

The paper uses TCR-epitope recognition models to analyze CD8+ T-cell responses in COVID-19 patients, finding that non-critical patients develop unique SARS-CoV-2-specific T-cell responses not seen in critical patients.