Author

Antonius M.J. VanDongen

Duke-NUS Medical SchoolORCID 0000-0002-9923-3407Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Yuheng JiangiD· 2 shared Gabriel Foo· 1 shared How-Wing Leung· 1 shared Juan Yin· 1 shared

Activity by Year

2020-2025 · peak 3/yr

Co-Author Collaboration Network

4 top collaborators · 1 mutual co-author link

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2 shared papersNeuroscience

Yuheng JiangORCID

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5 papers

Recent·Most cited

Arc: a therapeutic hub for Alzheimer's disease.

Antonius M.J. VanDongen

This paper identifies Arc as a therapeutic target for Alzheimer's disease by showing small molecules targeting Tip60 and PHF8 inhibit Arc expression, suggesting a multi-target approach.

bioRxiv · Jan 16, 2025 · PreprintNeuroscience

Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

How-Wing Leung, Gabriel Foo, Antonius M.J. VanDongen

This study shows Arc regulates neuronal gene expression and is linked to Alzheimer’s disease pathophysiology.

Biomedicines · Aug 11, 2022Peer-reviewedNeuroscience

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimers Disease

Juan Yin, Antonius M.J. VanDongen

This study generates AD patient-derived 3D brain organoids with PSEN2 mutation, showing increased Aβ42/Aβ40 ratio, asynchronous calcium transients, and neuronal hyperactivity.

ACS Biomaterials Science & Engineering · Dec 21, 2020Peer-reviewedNeuroscience

Selective increase of functional network connectivity in Arc-positive neuronal engrams after long-term potentiation

Yuheng Jiang, Antonius M.J. VanDongen

The paper investigates how Arc-positive neurons, marked by long-term potentiation, show increased functional connectivity and network refinement compared to c-Fos-expressing neurons.

bioRxiv · Dec 7, 2020 · PreprintNeuroscience

Neuronal Activity-Dependent Accumulation of Arc in Astrocytes

Yuheng Jiang, Antonius M.J. VanDongen

This study shows that Arc protein accumulates in astrocytes after neuronal activity, independent of astrocytic transcription, through intercellular transfer from neurons.

bioRxiv · Nov 10, 2020 · PreprintNeuroscience