Molecular BiologybioRxivPreprint
Curing genetic skin disease through altered replication stress response
T. Miyauchi, Shotaro Suzuki, Masae Takeda…·Toshifumi Nomura
The paper shows that mutant CARD14 proteins induce DNA double-strand breaks under replication stress, leading to homologous recombination and reversion of pathogenic mutations in genetic skin diseases.
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