The RNA-dependent interactions of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization.
Martin Sztacho, Jakub Červenka, Barbora Šalovská, Ludovica Antiga, Peter Hoboth, Pavel Hozák
This study identifies RNA-dependent PIP2-associated proteins in human cells and shows their role in nuclear compartmentalization through phase separation.
PLoS Genetics · Dec 2, 2024Peer-reviewedCell Biology