PARP inhibitors affect the replisome and replication fork progression during a single S phase.
Lina-Marie Briu, Chrystelle Antoinat Maric, Nicolas Valentin, Nicolas Panara, Guillaume Chevreux, Giuseppe Baldacci, Jean‐Charles Cadoret
This study investigates how PARP inhibitors affect DNA replication by causing replicative stress, altering replication timing, and disrupting replisome dynamics in human cells.
bioRxiv · Feb 20, 2025 · PreprintMolecular Biology