Author

Joshua I. Steinberg

Cold Spring Harbor LaboratoryORCID 0000-0002-9962-0394Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Andrea J. SchorniD· 3 shared Matthew PeaceyiD· 2 shared Asad A. LakhaniiD· 1 shared Benjamin RocheiD· 1 shared Daisy Rubio· 1 shared Helene SertznigiD· 1 shared Jenna Wilken· 1 shared John J. DesmaraisiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Andrea J. SchornORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 22, 2026

3'-tRNA Fragments Target Domesticated LTR-Retrotransposons

Matthew Peacey, Joshua I. Steinberg, Andrea J. Schorn

The paper shows 3'-tRNA fragments repress murine LTR-retrotransposons by targeting their tRNA primer binding site, revealing a role in gene regulation.

DOI 10.64898/2026.01.22.698655

mousebulk RNA-seq

Molecular BiologybioRxivPreprintMay 12, 2025

HENMT1 restricts endogenous retrovirus activity by methylation of 3'-tRNA fragments

Joshua I. Steinberg, Helene Sertznig, John J. Desmarais…·Andrea J. Schorn

This study identifies HENMT1 as a methyltransferase that protects 3'-tRNA fragments from degradation, enhancing their ability to silence endogenous retroviruses.

1 citation

mouseDNA methylation

GeneticsNature CommunicationsPeer-reviewedFeb 22, 2022

Dicer promotes genome stability via the bromodomain transcriptional co-activator Brd4.

Michael J. Gutbrod, Benjamin Roche, Joshua I. Steinberg…·Robert A. Martienssen

The paper identifies Brd4 as a suppressor of genome instability in Dicer1-/- mouse embryonic stem cells, showing its role in coordinating transcription and replication of satellite repeats.

23 citations

mouseDNA methylation