Beyond additivity: zero-shot methods cannot predict impact of epistasis on protein properties and function
Anastasia Kolchina, Igors Dubanevics, Fyodor A. Kondrashov, Olga V. Kalinina
The paper evaluates zero-shot models' ability to predict epistatic effects on protein properties and finds they fail to predict strongly epistatic mutation combinations.
bioRxiv · Jul 6, 2026 · PreprintBioinformatics