Author

Anastasia Kolchina

Helmholtz Centre for Infection ResearchORCID 0009-0001-3115-8279Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Fyodor A. KondrashoviD· 1 shared Igors DubanevicsiD· 1 shared Olga V. KalininaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBioinformatics

Fyodor A. KondrashovORCID

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintJul 6, 2026

Beyond additivity: zero-shot methods cannot predict impact of epistasis on protein properties and function

Anastasia Kolchina, Igors Dubanevics, Fyodor A. Kondrashov, Olga V. Kalinina

The paper evaluates zero-shot models' ability to predict epistatic effects on protein properties and finds they fail to predict strongly epistatic mutation combinations.

3 citations

protein sequencestatistical model

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