Enterovirus Evolution Reveals the Mechanism of an RNA-Targeted Antiviral and Determinants of Viral Replication
Jesse Davila‐Calderon, Mei-Ling Li, Srinivasa R. Penumutchu, Christina M. Haddad, Linzy Malcolm, Josephine King, Amanda E. Hargrove, Gary Brewer, Blanton S. Tolbert
This study identifies how antiviral resistance mutations in Enterovirus-A71 alter RNA structure and interactions, revealing mechanisms of DMA-135 action and viral resistance.
Science Advances · Feb 16, 2024Peer-reviewedMolecular Biology