Author

Jacob Luo

National Institutes of HealthORCID 0000-0003-0018-4850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Organism:multiple species· 1 Research Focus:phylogenetics / evolution· 1 Assay:protein sequence· 1 Approach:statistical model· 1

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Eugene V. KooniniD· 1 shared Victor TobiassoniD· 1 shared Yuri I. WolfiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperEvolutionary Biology

Eugene V. KooninORCID

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1 paper

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Evolutionary BiologyNaturePeer-reviewedJan 14, 2026

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Dominant contribution of Asgard archaea to eukaryogenesis

Victor Tobiasson, Jacob Luo, Yuri I. Wolf, Eugene V. Koonin

Constrained-tree hypothesis testing on 4,290 core eukaryotic protein clusters attributes 50% of likelihood weight to Asgard archaea; Alphaproteobacterial ancestry is largely confined to oxidative phosphorylation and iron-sulfur cluster biogenesis.

40 citationstop 1%

multiple speciesprotein sequence

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