Chen Zhang

This study investigates immune and metabolic changes in individuals adapting to high altitude using single-cell transcriptomics and metabolomics, revealing immune activation and metabolic shifts linked to adaptation.

The paper develops population-specific brain charts for Chinese individuals, revealing distinct neurodevelopmental patterns compared to Western populations and showing better performance in predicting brain phenotypes.

The paper identifies the prevalence and phenotypic impact of loss of function mutations in the MC4R gene in a UK birth cohort, finding a 0.30% carrier rate with significant effects on body weight and BMI.