Brian Lam

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

The paper creates a spatio-cellular map of the mouse nodose ganglia using single nucleus RNA sequencing and spatial transcriptomics, revealing subtype-specific gene expression and spatial organization.

This study shows that enteropancreatic neurons expressing NTSR1 mediate olive oil's effect on glucose tolerance by stimulating insulin release.

This study identifies biallelic SREK1 variants causing a Prader-Willi-like syndrome with obesity and hypotonia in consanguineous children.

This study shows that adult oligodendrogenesis in the median eminence regulates glucose homeostasis through ADAMTS4 expression, impacting the blood-hypothalamus barrier and neuronal glucose sensing in the arcuate nucleus.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

The paper presents HYPOMAP, a comprehensive spatio-cellular map of the human hypothalamus, identifying BMI-associated genes and potential druggable targets.

The paper identifies protein-truncating variants in BSN associated with severe adult-onset obesity, type 2 diabetes, and fatty liver disease, with no effect on childhood adiposity.

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

This study identifies brainstem GLP-1 neurons as essential for lorcaserin's effect on reducing food intake in mice and suggests combination therapy with GLP-1R agonists may enhance efficacy.

This study shows that the imprinted Igf2-Igf2r axis is essential for coordinating placental microvasculature expansion with fetal growth in mice.

The paper identifies the prevalence and phenotypic impact of loss of function mutations in the MC4R gene in a UK birth cohort, finding a 0.30% carrier rate with significant effects on body weight and BMI.

The paper uses single-nucleus RNA sequencing to analyze the mouse hindbrain's AP and NTS in fed and fasted states, identifying transcriptional changes and receptor expression patterns relevant to obesity therapies.

This study identifies mesenchymal Igf2 as a critical paracrine regulator of pancreatic growth and function through in vivo and ex vivo experiments.

The paper shows that transcription starts much earlier in mouse and human one-cell embryos than previously thought, driven mainly by the maternal genome.

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.

This study investigates the distinct roles of fetal and trophoblast PI3Kp110α in regulating nutrient supply to the fetus, showing differential effects on placental function and fetal growth.

The paper uses single-cell RNA sequencing to reveal heterogeneity in murine hypothalamic POMC neurons, identifying distinct subpopulations with different gene expression profiles and receptor expression.