Genetic & Genomic MedicineCell GenomicsPeer-reviewed
Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship
Kenneth E. Westerman, Julie E Gervis, Luke Jen O’Connor…·Alisa Knodle Manning
The paper develops a pipeline to compare polygenic scores (PGS) for detecting genetic interactions between adiposity and cardiometabolic risk factors, finding that interaction-based PGS (iPGS) most consistently identifies these interactions.
4 citations