Author

Zhuoran Hou

Duke UniversityORCID 0000-0003-0195-9056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Research Focus:polygenic risk· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alejandro OchoaiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

2 papers

Recent·Most cited

GeneticsGeneticsPeer-reviewedNov 5, 2025

Kinship estimation bias carries over to heritability estimation bias using variance components

Zhuoran Hou, Alejandro Ochoa

This study shows that biased kinship estimation in structured populations leads to heritability estimation bias, with Popkin being the only unbiased estimator.

DOI 10.1093/genetics/iyaf238

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsGeneticsPeer-reviewedFeb 27, 2023

Genetic association models are robust to common population kinship estimation biases

Zhuoran Hou, Alejandro Ochoa

This study shows genetic association models like PCA and LMM are robust to common kinship estimation biases in structured populations.

8 citations

GWAS summary statisticsstatistical model

𝕏 PostBluesky