Author

Burkhard Hirsch

Charité – Universitätsmedizin BerlinORCID 0000-0003-0214-756XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Anja DrögeiD· 2 shared Dominik BentsiD· 2 shared Kristin GennermanniD· 2 shared Nadine GenzeliD· 2 shared Sefer ElezkurtajiD· 2 shared Sigrid Schaper· 2 shared Steffen HennigiD· 2 shared Volkhard SeitziD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersImmunology

Anja DrögeORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 24, 2026

Tumor-versus-non-tumor T cell enrichment supported by single-cell and spatial phenotyping enables antigen-agnostic prioritization of candidate tumor-reactive TCRs

Volkhard Seitz, Jannik Franzen, Kristin Gennermann…·Sefer Elezkurtaj

The paper identifies tumor-reactive TCRs using T/N ratios and validates them with single-cell and spatial data, showing their tumor association and effector phenotype.

DOI 10.64898/2026.09.18.750832

humanscRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintApr 26, 2025

A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity

Steffen Hennig, Kristin Gennermann, Sefer Elezkurtaj…·R. Hammer

This paper introduces a TCR-V(D)J-sequence clustering method to identify tumor-specific common TCRs across cancers, showing their pan-cancer reactivity and potential for therapeutic applications.

DOI 10.1101/2025.04.26.650660

humanCITE-seq

𝕏 PostBluesky