Michael Yarus

The paper explores how RNA-amino acid interactions at specific frequencies could lead to the emergence of the Standard Genetic Code through a kinetic model and evolutionary mechanisms.

The paper models the evolution of the Standard Genetic Code through computational simulations of code division and fusion, identifying the most efficient pathways for its emergence.

This paper demonstrates that a code fusion mechanism (c3-lCw) can evolve the Standard Genetic Code (SGC) more efficiently than other methods.

The paper constructs minimally-evolved genetic codes and shows that late Crick wobble enables efficient packing of a highly ordered code into a fixed 3D space.

The paper proposes a principle of least selection to explain how favored biological characteristics evolve through paths that minimize selection pressure, leading to faster and more probable evolutionary changes.

The paper explores the evolution of the Standard Genetic Code by simulating plausible evolutionary paths and quantifying progress toward the SGC using defined metrics.