Inferring spatial gene expression from tissue images using large-scale histology foundation model with SpaFoundation
Ning Zhang, Yahui Long, Sibo Xia, Pengzhen Jia, Yujie Jin, Siqi Chen, Jinmiao Chen, Min Li
This paper introduces SpaFoundation, a histology foundation model that predicts spatial gene expression from tissue images, showing strong performance in prediction and transferability.
bioRxiv · Aug 7, 2025 · PreprintBioinformatics