Translational products encoded by novel ORFs may form protein-like structures and have biological functions
Chaitanya Erady, David Chong, Narendra Kumar Meena, Shraddha S. Puntambekar, Ruchi Chauhan, Yagnesh Umrania, Adam Andreani, Jean Henri Nel, Matthew Thomas Wayland, Cristina Pina, Kathryn Susan Lilley, Sudhakaran Prabakaran
The paper shows that novel ORFs can produce protein-like structures with biological functions relevant to disease, challenging the view that they are inconsequential.
bioRxiv · Mar 5, 2019 · PreprintGenetics