Cristina Pina

Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

This paper introduces a 3D hemogenic gastruloid model to study infant acute myeloid leukemia origins, showing MNX1-driven transformation of erythroid-myeloid progenitors.

Integrated in silico and in vitro approaches identify a HSP90 drug vulnerability axis in t(7;12) infant leukemia stem-like cells

The paper identifies HSP90 inhibitors as potential therapies for t(7;12)-AML by combining computational drug screening with in vitro experiments.

Translational products encoded by novel ORFs may form protein-like structures and have biological functions

The paper shows that novel ORFs can produce protein-like structures with biological functions relevant to disease, challenging the view that they are inconsequential.

Histone Acetyltransferase Kat2a Stabilises Pluripotency with Control of Transcriptional Heterogeneity

The paper shows that inhibiting Kat2a increases transcriptional heterogeneity in mouse embryonic stem cells, leading to reduced pluripotency and accelerated differentiation.