Paul M Hofman

This study identifies three distinct evolutionary trajectories in lung adenocarcinomas using whole-genome sequencing, revealing that some never-smoking tumors follow smoking-like paths driven by KRAS mutations.

This study shows glucocorticoids increase P-body numbers and alter mRNA translation fate based on transcript sequence features, not abundance.

The paper maps shared epitopes across human and murine proteins to address immune recognition challenges and provides a web server for epitope detection.

The paper identifies three subtypes of NS-LUAD using RNA-seq data and develops a 60-gene signature that predicts survival across subgroups.

This study analyzes 1024 lung adenocarcinomas to identify evolutionary patterns and mutational mechanisms, revealing distinct trajectories linked to smoking, ancestry, and retrotransposition.