Author

Takeshi Ōmasa

Manufacturing Technology Association of BiologicsORCID 0000-0003-0635-3862Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:large language model· 1 Organism:rat· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Akihisa Shina· 1 shared Aoi HosakaiD· 1 shared Hiromu Kurita· 1 shared Kazuhisa UchidaiD· 1 shared Keiro Watanabe· 1 shared Masamichi KamihiraiD· 1 shared Norichika OgataiD· 1 shared Noriko HashibaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioengineering

Akihisa Shina

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 30, 2026

Harness engineering enables a multi-agent LLM system to generate cross-domain hypotheses beyond single-investigator reach

Takeshi Ōmasa, Keiro Watanabe

The paper demonstrates that a well-designed prompting system outperforms model upgrades in generating scientific hypotheses, introducing a framework to create falsifiable, cross-domain hypotheses.

DOI 10.64898/2026.10.25.761203

large language modelbenchmarking

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BioengineeringbioRxivPreprintFeb 14, 2025

Database Chemistry for Genomics-Based Safety and Quality Evaluation of Biologics

Norichika Ogata, Tomoko Matsuda, Aoi Hosaka…·Takeshi Ōmasa

The paper evaluates the impact of reference genome accuracy on biologics safety and proposes methods to improve it using Chinese hamster genome data.

DOI 10.1101/2025.02.14.638017

ratwhole-genome sequencing

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