Author

Sudha Chakrapani

Case Western Reserve UniversityORCID 0000-0003-0722-2338Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Abba E. LeffleriD· 1 shared Edward B. MilleriD· 1 shared Kevin C. FeltiD· 1 shared Lindsay DenluckiD· 1 shared Lingle WangiD· 1 shared Martin VögeleiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiophysics

Abba E. LefflerORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintSep 24, 2026

State-specific binding thermodynamics predicts ligand efficacy across ion-channel families.

Martin Vögele, Abba E. Leffler, Kevin C. Felt…·Lingle Wang

The paper uses free energy perturbation to predict ligand efficacy in ion channels by analyzing state-specific binding thermodynamics across multiple families.

DOI 10.64898/2026.09.22.753602

protein structurestatistical model

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