Owen J. Melia

BrainXcan uses genetic and imaging data to identify brain features linked to psychiatric traits, finding reduced axonal density and hippocampal features associated with schizophrenia risk.

PhenomeXcan integrates GWAS and transcriptomic data to identify gene-trait associations, providing a resource for translational research with biological context.

The paper improves causal gene identification and transcriptome prediction by integrating fine-mapping and QTL tissue-sharing information into transcriptomic imputation models.