Ataxia-Telangiectasia Mutated Inhibition Enhances Adeno-Associated Virus-Mediated Knock-in Efficiency in Pig Zygotes
Hiromasa Hara, Mitsuhiro Noguchi, Fuminori Tanihara, Makoto Inoue, Yutaka Hanazono, Arata Honda
The paper shows that inhibiting ATM with AZ32 improves AAV-mediated long-fragment knock-in efficiency in pig zygotes, enabling double knock-in at two loci.
bioRxiv · Dec 23, 2025 · PreprintBioengineering