Can We Extract Physics-like Energies from Generative Protein Diffusion Models?
Sudeep Sarma, Harrison H. Truscott, Da Zhuan Xu, Kendall A. Reid, Lee‐Shin Chu, Jacky H. K. Chen, Jeffrey J. Gray
This paper examines whether diffusion models can extract physics-like energies for protein docking, finding they can recover energy funnels comparable to Rosetta in 9 out of 25 cases.
bioRxiv · Nov 28, 2025 · PreprintBiophysics