Author

Madhusmita Das

Schieffelin Institute of Health Research and Leprosy CentreORCID 0000-0003-0848-2035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:protein structure· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Sundeep Chaitanya VedithiiD· 3 shared Sony MalhotraiD· 2 shared Tom L. BlundelliD· 2 shared Ali F. AlsulamiiD· 1 shared Annemieke GelukiD· 1 shared Anouk van HooijiD· 1 shared Asma MuniriD· 1 shared Carlos H. M. RodriguesiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBioinformatics

Sundeep Chaitanya VedithiORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 29, 2026

✦ In-depth digest

HANSEN: An Integrated Structural and Functional Proteome Resource for Structure-Guided Drug Discovery in Mycobacterium leprae

Sundeep Chaitanya Vedithi, Rebecca Rees, Sony Malhotra…·Rodrigo Andres Floto

Web resource offering predicted monomeric and oligomeric structures for 1,603 M. leprae proteins, with pockets, epitope scores, essentiality and a target priority ranking, plus a nanopore resistance-calling module.

DOI 10.64898/2026.08.03.741541

bacteria (other)protein structure

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Molecular BiologyFrontiers in MicrobiologyPeer-reviewedMar 27, 2023

Mycobacterium leprae and host immune transcriptomic signatures for reactional states in leprosy

Madhusmita Das, Diana David, Ilse Horo…·Sundeep Chaitanya Vedithi

The paper identifies M. leprae and host gene-expression signatures associated with type I and II reactions in leprosy using transcriptomic analysis of skin biopsies.

6 citations

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintJun 11, 2019

Computational Saturation Mutagenesis to predict structural consequences of systematic mutations on protein stability and rifampin interactions in the β subunit of RNA polymerase in Mycobacterium leprae

Sundeep Chaitanya Vedithi, Carlos H. M. Rodrigues, Stephanie Portelli…·Sony Malhotra

DOI 10.1101/654095

protein structurestatistical model

𝕏 PostBluesky