Sanjarbek Hudaiberdiev

The paper identifies and characterizes HOT loci in the human genome, showing they are widespread and formed by large transcriptional condensates, challenging the classical model of enhancer activity.

ChromDL is a deep learning model that improves the classification of regulatory DNA elements by combining BiGRU, CNN, and BiLSTM architectures, outperforming previous methods in TFBS, HM, and DHS detection.