Richard L. Kingston

The paper reviews the evolutionary history of cotranscriptional editing in paramyxoviruses, showing multiple switches between P and V default modes and losses of the editing system.

The paper compares 12 stochastic transcription elongation models using Bayesian inference and force-velocity data from E. coli, S. cerevisiae, and T7 polymerases, showing differences in translocation rates and model applicability.

The paper compares 128 kinetic models of transcriptional pausing using approximate Bayesian computation to predict pause site locations in E. coli, finding structural parameters and translocation dynamics are key, while hypertranslocation and backtracking are not required.