Stephen M. Prince

This study uses simulations to reveal how ATP binding and hydrolysis drive drug egress through P-glycoprotein by coordinating transmembrane domain motions and nucleotide states.

This study uses computational analysis to explore how nucleotide states and ligand binding in P-glycoprotein influence drug transport and allosteric signaling.

This study investigates the role of the linker domain in ABCB1/P-glycoprotein using simulations, cryo-EM, and computational methods, revealing its impact on protein structure and function.

This study uses computational methods to investigate how nucleotide asymmetry and linker dynamics influence the drug efflux mechanism of P-glycoprotein.