Author

Guanglei Yu

Central South UniversityORCID 0000-0003-0956-9028Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:contrastive learning· 1 Approach:deep learning· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

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Jianxin WangiD· 1 shared Qichang ZhaoiD· 1 shared Xuehua BiiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperMolecular Biology

Jianxin WangORCID

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1 paper

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Molecular BiologyBioinformaticsPeer-reviewedJul 1, 2026

USP-ddG: A Unified Structural Paradigm with Data Efficacy and Mixture-of-Experts for Predicting Mutational Effects on Protein-Protein Interactions

Guanglei Yu, Xuehua Bi, Qichang Zhao, Jianxin Wang

USP-ddG predicts mutational effects on protein-protein interactions by improving data efficiency and modeling conformational dynamics, outperforming existing methods on benchmark datasets.

DOI 10.1093/bioinformatics/btag249

protein structuredeep learning

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