Jay C. Brown

The paper identifies 15 candidate cytoplasmic retention peptides in human proteins, with 10 having unrelated sequences, and shows that retention sequences are located at specific sites across protein isoforms.

The paper investigates the effect of a truncated LINE1 sequence (t1519) on gene expression, finding it suppresses expression in long protein-coding genes and certain lncRNA genes.

The paper investigates promoter architecture in human brain and liver specific genes, finding that backup transcription factor binding sites provide redundancy to protect gene expression from mutations.

The paper compares promoter regions of broadly expressed and tissue-targeted transcription factor genes to identify regulatory differences, finding enrichment of POLR2A and EZH2 respectively.

The paper analyzes testis-specific genes to identify regulatory features and patterns associated with differentiation levels in human testis cells.