Thomas Fleischer

This study integrates DNA methylation, gene expression, and metabolic profiles to identify molecular pathways and signatures associated with aggressive prostate cancer and disease recurrence.

This study shows that paclitaxel resistance in triple-negative breast cancer is linked to DNA methylation changes, which can be partially reversed by decitabine to enhance chemosensitivity.

The paper uses scRNA-seq and explainable machine learning to analyze how tumor microenvironment cell types affect neoadjuvant chemotherapy outcomes in breast cancer.