Sex-specific interactions between procedural and deliberative decision-making systems in a mouse model of Alzheimer's disease
Rachel M. Anderson, Damyan W. Hart, Brian M. Sweis, Mathew A. Sherman, Mark John Thomas, A. David Redish, Sylvain Lesné
The paper shows that APP mice, a model of Alzheimer's disease, exhibit sex-specific changes in decision-making strategies, with impaired procedural cognition and reliance on deliberation, linked to striatal amyloid-beta pathology.
bioRxiv · Mar 16, 2021 · PreprintNeuroscience